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Agenda
Tentative Agenda - all times are in EST.
Tuesday, October 26, 2021
| Time | Title/Topic Event |
| 8:30 AM - 8:45 AM | Welcome Address from the Conference Organizers: Barbara Niemeyer, University of Saarland, Germany and Nicolas Demaurex, University of Geneva, Switzerland |
| 8:45 AM – 9:25 AM | Sir Michael Berridge Memorial LECTURE Ole Petersen, Cardiff University, UK Sir Michael's Legacy: Importance of the Discoveries and their Implications Moderator: Anant Parekh, NIH, Oxford |
| 9:25 AM – 9:30 AM | Live Q&A |
| 9:30 AM - 11:40 AM | General Session I: NOVEL APPROACHES FOR STUDYING Ca2+ SIGNALING IN LIVING CELLS Session Chair: Yubin Zhou, Texas A&M, University, Houston, USA |
| 9:30 AM – 9:50 AM | Won Do Heo, KAIST, Seoul, South Korea Optogenetic control of endogenous Ca2+ channels in living cells and living animals |
| 9:50 AM - 10:10 AM | Jin Zhang, UCSD, La Jolla, CA, USA Biosensor imaging and computational modeling to dissect signaling nanodomains and oscillations in living cells |
| 10:10 AM – 10:20 AM | Short Talk 1: Yves Gouriou, INSERM, Lyon, France - NOT AVAILABLE ON DEMAND High-sensitivity calcium sensor on mitochondrial surface for exploring low calcium dynamics |
| 10:20 AM – 10:35 AM | Live Q&A |
| 10:35 AM – 10:55 AM | Jenny Yang, Georgia State University, USA Catching Temporal and Spatial Calcium Dynamics |
| 10:55 AM – 11:15 AM | Oliver Griesbeck, MPG, Germany New fluorescent biosensors for intra- and extracellular calcium |
| 11:15 AM – 11:25 AM | Short Talk 2 Lian He, Texas A&M University, Houston, USA Engineering of a bona fide light-operated calcium channel |
| 11:25 AM – 11:40 AM | Live Q&A |
| 11:40 AM - 12:00 PM | Break |
| 12:00 PM – 1:00 PM | Career Development Session: Kevin Foskett, University of Pennsylvania, USA; Gaiti Hasan, National Centre for Biological Sciences, India; Yishan Sun, Novartis Institutes for BioMedical Research, USA Moderator: Nicolas Demaurex, University of Geneva, Switzerland |
| 1:00 PM – 2:00 PM | Poster Session 1 |
| 2:00 PM – 4:10 PM | Session II: Membrane Contact Sites - Novel Signaling Hubs Session Chair: Nicolas Demaurex, University of Geneva, Switzerland |
| 2:00 PM – 2:20 PM | Fabiana Perocchi, Helmholtz Munich, Germany Multiomics analysis of interorganelle crosstalk |
| 2:20 PM – 2:40 PM | György Hajnoczky, Thomas Jefferson University, Philadelphia, USA - NOT AVAILABLE ON DEMAND Calcium and ROS signaling at the ER-mitochondrial contacts sites |
| 2:40 PM – 2:50 PM | Short Talk 3 Amado Carreras-Sureda, University of Geneva, Switzerland. ER-stress sensor IRE1 promotes STIM1 to locate to ER/PM contact sites favoring SOCE T cell activation and muscular differentiation |
| 2:50 PM – 3:05 PM | Live Q&A |
| 3:05 PM – 3:25 PM | Tamas Balla, NIH, Bethesda, USA Dynamic regulation of Ca2+ fluxes at membrane contact sites |
| 3:25 PM – 3:45 PM | Mathieu Brochet, University of Geneva, Switzerland Taking life-changing decisions in ten seconds: calcium signaling in malaria parasites |
| 3:45 PM – 3:55 PM | Short Talk 4 Jinghui Jiang, Tsinghua University, Beijing, China Tethering Piezo channels to the actin cytoskeleton for mechanogating via the cadherin-β-catenin mechanotransduction complex |
| 3:55 PM - 4:10 PM | Live Q&A |
| 4:10 PM – 4:30 PM | Break |
| 4:30 PM - 6:40 PM | Session III: STORE-OPERATED CA2+ ENTRY Session Chair: Jen Liou, University of Texas, Southwestern Medical Center |
| 4:30 PM – 4:50 PM | Don Gill, Penn State University, USA Molecular Coupling across the ER-PM Ca2+ Signaling Interface |
| 4:50 PM – 5:10 PM | Huijuan Hu, Rutgers NJ Medical School, USA STIM/Orai signaling and pain |
| 5:10 PM – 5:20 PM | Short Talk 5 Vanessa Poth, Saarland University, Germany. New STIM1 and STIM2 splice variants - SOCE, NFAT and tissue specificity |
| 5:20 PM – 5:35 PM | Live Q&A |
| 5:35 PM – 5:55 PM | Indu Ambudkar, NIH, Bethesda, USA - NOT AVAILABLE ON DEMAND IP3R and STIM2 – a coordinated early response team that efficiently regulates agonist-stimulated Ca2+ signaling |
| 5:55 PM – 6:15 PM | Stefan Feske, NYU, USA Cavb1 regulates T cell function independently of voltage-gated Ca2+ channel function |
| 6:15 PM - 6:25 PM | Short Talk 6 Lena Maltan, University Linz, Austria Light-induced CRAC-channel like Orai1 activation independent of STIM1 |
| 6:25 PM - 6:40 PM | Live Q&A |
| 6:40 PM - 6:50 PM | Conclusion - End of Day I |
Wednesday, October 27, 2021
| Time | Title/Topic Event |
| 8:30 AM – 8:40 AM | Welcome to Day II Conference Organizers: Barbara Niemeyer and Nicolas Demaurex |
| 8:40 AM - 10:50 AM | Session IV: Calcium and contraction Session Chair: Mohamed Trebak, University of Pittsburgh, USA |
| 8:40 AM – 9:00 AM | Andrew Marks, Columbia University NY, USA Ryanodine Receptor Structure and Function in health and disease |
| 9:00 AM - 9:20 AM | Johanna Lanner, Karolinska Institutet, Stockholm, Sweden Intramuscular stress and mitochondrial alterations in inflammation-associated muscle weakness |
| 9:20 AM – 9:30 AM | Short Talk 7 Johann Bohm, University of Strasbourg, France New insights into the pathophysiological effect of calcium overload in skeletal muscle |
| 9:30 AM – 9:45 AM | Live Q&A |
| 9:45 AM – 10:05 AM | Bernard T. Drumm, Dundalk Institute of Technology, Ireland Ca2+ signals in interstitial cells of Cajal that drive gastrointestinal motility |
| 10:05 AM – 10:25 AM | Cristina Mammucari, University of Padova, Italy - NOT AVAILABLE ON DEMAND Mitochondrial calcium signalling regulates skeletal muscle homeostasis in adulthood and aging |
| 10:25 AM – 10:35 AM | Short Talk 8 Jeremy Smyth, Uniformed Services University Septins regulate heart contractility through modulation of cardiomyocyte store-operated calcium entry |
| 10:35 AM – 10:50 AM | Live Q&A |
| 10:50 AM - 11:10 AM | Break |
| 11:10 AM – 12:10 PM | Meet the Experts: How to avoid bias in Academia Sharona Gordon, University of Washington, Seattle, USA Moderators: Christine Peinelt, University of Bern, Switzerland; Khaled Machaca, Weill Cornell Medicine, Qatar |
| 12:10 PM – 1:30 PM | Poster Session II |
| 1:30 PM – 3:45 PM | Session V: MOLECULAR MECHANISMS OF Ca2+ CHANNELS AND SIGNALING PROTEINS Session Chair: David Yule, University of Rochester, USA |
| 1:30 PM – 1:50 PM | Alexander Sobolevsky; Columbia University, USA Structure and Function of the calcium-selective TRP channel TRPV6 |
| 1:50 PM – 2:10 PM | Peter B. Stathopulos, Western University, Canada - NOT AVAILABLE ON DEMAND The MCUR1 matrix domain solution structure unmasks a pH sensing function |
| 2:10 PM – 2:20 PM | Short Talk 9 Shu-Hsien Sheu, Janelia Research Campus, USA A serotonergic axon-cilium synapse |
| 2:20 PM – 2:35 PM | Live Q&A |
| 2:35 PM – 2:55 PM | Sharona Gordon, University of Washington, USA Feedback Regulation of TRPV1 Ion Channels |
| 2:55 PM – 3:20 PM | Geert Bultynck, University of Leuven, Belgium Resemblance in the Bcl-2 family: the Bcl-2/Bcl-XL brothers both function as IP3 receptor inhibitors |
| 3:20 PM – 3:30 PM | Short Talk 10 Erkan Karakas, Vanderbilt University, USA Structural basis for activation and gating of IP3 receptor calcium channels |
| 3:30 PM - 3:40 PM | Short Talk 11 Rajesh Bhardwaj, NIH, USA Dissecting gating mechanisms of Orai calcium channel paralogs using constitutively active Orai mutants that mimic STIM1-gated state |
| 3:40 PM – 4:00 PM | Live Q&A |
| 4:00 PM – 4:10 PM | Conclusion - End of Day II |
Thursday, October 28, 2021
| Time | Title/Topic Event |
| 8:30 AM – 8:40 AM |
Welcome to Day III |
| 8:40 AM - 10:50 AM | Session VI: NEURONAL/Glial SIGNALING Session Chair: Barbara Niemeyer, University of Saarland, Germany |
| 8:40 AM – 9:00 AM | Amit Agarwal, Heidelberg, Germany - NOT AVAILABLE ON DEMAND Decoding mitochondrial structure and calcium dynamics in astrocytes |
| 9:00 AM - 9:20 AM | Yishan Sun, Novartis Neuroscience, Cambridge, USA L-type calcium channel (LTCC) signaling in psychotic and mood disorders |
| 9:20 AM – 9:30 AM | Short Talk 12 Daniela Menichella, Northwestern University Mitochondrial Calcium Uniporter (MCU) Deletion Prevents Painful Diabetic Neuropathy by Restoring Mitochondrial Morphology and Dynamics |
| 9:30 AM – 9:45 AM | Live Q&A |
| 9:45 AM - 10:05 AM | Murali Prakriya, Northwestern University, Chicago, USA SOCE in astrocytes and neurons |
| 10:05 AM – 10:25 AM | Ilya Bezprozvanny, UT Southwestern, Dallas, Texas, USA Sigma 1 receptor as regulator of ER signaling |
| 10:25 AM – 10:35 AM | Short Talk 13 Thirumalini Vaithianathan, University of Tennessee, USA Nanoscale dynamics of calcium signals at presynaptic active zone of ribbon synapses |
| 10:35 AM – 10:50 AM | Live Q&A |
| 10:50 AM – 11:10 AM | Break |
| 11:10 AM – 12:10 PM | Meet the Experts: The Art of Publishing Your Science Speakers: Shmuel Muallem, NIH, USA; Darla Henderson, FASEB, USA Moderators: Yubin Zhou, Texas A&M, University, Houston, USA and Barbara Niemeyer, University of Saarland, Germany |
| 12:10 PM – 1:30 PM | Poster Session III |
| 1:30 PM – 3:40 PM | Session VII: CALCIUM SIGNALING AT MITOCHONDRIA AND LYSOSOMES Session Chair: Anant Parekh, Oxford University, UK |
| 1:30 PM – 1:50 PM | Christian Grimm, LMU Munich, Germany - NOT AVAILABLE ON DEMAND TRPML and two-pore channels in endo-lysosomal trafficking and disease |
| 1:50 PM – 2:10 PM | Rosario Rizzuto, University of Padova, Italy The MCU complex in health and disease |
| 2:10 PM – 2:20 PM | Short Talk 14 Maria Patron, Max Planck institute, Cologne, Germany TMBIM5 a new mitochondrial calcium channel |
| 2:20 PM – 2:35 PM | Live Q&A |
| 2:35 PM – 2:55 PM | Mélanie Paillard, INSERM, Lyon, France Disruption of ER-mito Ca2+ transfer in metabolic diseases |
| 2:55 PM – 3:15 PM | Elizabeth Murphy, NIH, Bethesda, USA Mitochondrial calcium signaling in cardiac function and dysfunction |
| 3:15 PM – 3:25 PM | Short Talk 15 Björn-Philipp Diercks, University Medical Center Hamburg-Eppendorf, Germany Mechanisms of NAADP synthesis in T cells |
| 3:25 PM - 3:40 PM | Live Q&A |
| 3:40 PM – 4:00 PM | Break |
| 4:00 PM – 4:40 PM | Session VIII: LATE BREAKING TOPICS Session Chair: Aldebaran Hofer, Harvard University, USA |
| 4:00 PM – 4:20 PM | Israel Sekler, Ben Gurion University, Israel Essential role of NCLX in learning and hepatic hormonal signaling is controlled by PDE2 |
| 4:20 PM – 4:30 PM | Short Talk 16 Jessica Moore, Yale University, USA Tissue-wide coordination of calcium signaling regulates the epithelial stem cell pool during homeostasis |
| 4:30 PM – 4:40 PM | Live Q&A |
| 4:40 PM - 5:25 PM | Keynote Speaker Richard Lewis, Stanford University, CA, USA Molecules in motion: mechanisms of store-operated calcium entry Moderators: Nicolas Demaurex, University of Geneva, Switzerland and Barbara Niemeyer, University of Saarland, Germany |
| 5:25 PM - 5:40 PM | Live Q&A |
| 5:40 PM – 6:00 PM | Conclusion of Day 3 – End of Conference |
