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Agenda
Please note that the agenda is subject to change. All talks will be pre-recorded with live question/answer periods, unless noted otherwise.The conference is taking place using the British Summer Time zone (BST). FOR EXAMPLE, AS A REFERENCE, PLEASE NOTE THAT 14:00 BST IS 9:00 AM EST.
| Tuesday, July 20, 2021 Day I |
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| Time – British Summer Time (BST) |
Event - VIRTUAL | |
| 14:00 – 14:10 (09:00 AM EST) |
Conference Opens - Welcome Day I Opening remarks by Conference Chair: Gareth Inman (CRUK Beatson Institute, UK) |
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| 14:10 – 16:10 | Session I: Signaling Mechanisms During Development and Disease Chair: Cathy Savage-Dunn (Conference Co-Chair) (City University of New York, USA) |
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| 14:10 – 14:30 | Caroline Hill (Francis Crick Institute, UK) Self-organising pattern formation in endoderm specification in zebrafish |
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| 14:30 – 14:50 | Mary Mullins (University of Pennsylvania, USA) BMPs in development |
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| 14:50 – 15:00 | Short talk 1 Mohammed Farhan Lakdawla (Texas Woman's University, USA) Characterizing the interactions of the DBL-1/BMP signaling pathway with BLMP-1/BLIMP1 transcription regulator in Caenorhabditis elegans |
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| 15:00 – 15:15 | Live Q&A Panel Discussion | |
| 15:15 – 15:35 | Aryeh Warmflash (Rice University, USA) Studying self-organized pattern formation with human embryonic stem cells |
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| 15:35 – 15:45 | Short talk 2 Lalage Wakefield (NIH, Bethesda, USA) A new TGF-β pathway reporter mouse for analysis of TGF-β signaling in normal homeostasis and cancer |
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| 15:45 – 15:55 | Short talk 3 Gregory Gipson (University of Cincinnati, USA) Exploring the unique biochemistry of an artificial BMP heterodimer |
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| 15:55 – 16:10 | Live Q&A Panel Discussion | |
| 16:10 – 16:30 | Break | |
| 16:30 – 17:05 | Keynote I: TGF-β receptor signaling in epithelial-mesenchymal plasticity of cancer cells Peter ten-Dijke (Universiteit Leiden, The Netherlands) Chair: Tom Thompson (University of Cincinnati, USA) |
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| 17:05 – 17:20 | Live Q&A Panel Discussion | |
| 17:20 – 18:20 | Poster Session I | |
| 18:20 – 20:20 | Session II: Signaling in Cancer Chair: Gareth Inman (CRUK Beatson Institute, UK) |
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| 18:20 – 18:40 | Yibin Kang (Princeton University, USA) Signaling in Metastasis |
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| 18:40 – 19:00 | Sabine Werner (ETH, Zurich, Switzerland) A key regulator of wound healing, scar formation and tumorigenesis |
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| 19:00 – 19:10 | Short talk 4 Yi He (McGill University, Canada) The CDC42/Rac1 regulator CdGAP is a molecular target of the TGFβ/Smad signaling pathway and promotes HER2-positive breast cancer growth and metastatis |
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| 19:10 – 19:25 | Live Q&A Panel Discussion | |
| 19:25 – 19:45 | Ming Li (MSKCC, USA) Modulation of the immune microenvironment |
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| 19:45 – 19:55 | Short talk 5 Yae Ohata (Uppsala University, Sweden) TGFβ differentiates pro-stemness from pro-invasive phenotypes during cancer cell EMT |
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| 19:55 – 20:05 | Short talk 6 Derek Brazil (Queens University, Belfast, UK) Mechanisms of GREM1 signaling in intestinal epithelial cells |
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| 20:05 – 20:20 | Live Q&A Panel Discussion | |
| 20:20 – 21:20 | Meet the Experts
Moderated by the Organizers: Gareth Inman; Cathy Savage-Dunn; Tom Thompson |
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| 21:20 – 21:30 | Conclusion of Day I | |
| Wednesday, July 21, 2021 | Day II |
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| Time – British Summer Time (BST) | Event - VIRTUAL FASEB | |
| 14:00 – 14:05 (09:00 AM EST) |
Conference Opens - Welcome Day II Opening Remarks by Conference Co-Chair: Tom Thompson |
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| 14:05 – 16:05 | Session III: Ageing, Metabolism and Repair Chair: Tom Thompson |
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| 14:05 – 14:25 | Richard T. Lee (Harvard University, USA) Update on the controversy on GDF11 and aging |
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| 14:25 – 14:45 | Lee Rubin (Harvard University, USA) Reversing the effects of aging on the brain: a new approach using recombinant GDF11 |
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| 14:45 – 14:55 | Short talk 7 Masato Morikawa (University of Tokyo, Japan) Systemic administration of monovalent follistatin-like 3-Fc-fusion protein increases muscle mass in mice |
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| 14:55 – 15:10 | Live Q&A Panel Discussion | |
| 15:10 – 15:30 | Aris Economides (Regeneron, USA) Why ACVR1 antibodies should not be considered as a disease-modifying therapy in FOP |
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| 15:30 – 15:40 | Short talk 8 Christina Stuelten (NIH, NCI, USA) Smurf2 loss leads to reduced skin scaring and increased scar stability |
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| 15:40 – 15:50 | Short talk 9 Mengistu Gebere (University of South Carolina, USA) Reduction in SMAD3 signaling was more potent than TGFβ1 ligand abatement to inhibit age related vascular calcification in Klotho deficient mice |
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| 15:50 – 16:05 | Live Q&A Panel Discussion | |
| 16:05 – 17:05 | Poster Session II | |
| 17:05 – 18:00 | Career Workshop: Career Pathways for Signaling Scientists Panelists: Caroline Hill; Aris Economides; Cathy Savage-Dunn; Tom Thompson; Gareth Inman; Alexia-Ileana Zaromytidou |
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| 18:00 – 18:40 | Keynote II: Signaling in Stem Cells Elaine Fuchs (The Rockefeller University, USA) Chair: Cathy Savage-Dunn (City University of New York, USA) |
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| 18:40 – 18:55 | Live Q&A Panel Discussion | |
| 18:55 - 19:00 | Break | |
| 19:00 – 21:00 | Session IV: Signal Modulation and Therapeutic Strategies Chair: Petra Knaus (Freie Universität, Berlin, Germany) |
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| 19:00 – 19:20 | Ravi Kumar (Acceleron, USA) Targeting the TGF-β superfamily therapeutically with ligand traps versus anti-ligand antibodies: balancing efficacy and safety |
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| 19:20 – 19:40 | Sophie Lucas (Université Catholique de Louvain, Belgium) Selective inhibition of TGF-b1 produced by GARP-expressing Tregs for the immunotherapy of cancer |
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| 19:40 – 19:50 | Short talk 10 Gonzalo Sanchez-Duffhues (Leiden University, The Netherlands) Cripto favors chondrocyte hypertrophy via TGF-beta SMAD1/5 signaling in experimental Osteoarthritis |
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| 19:50 – 20:05 | Live Q&A Panel Discussion | |
| 20:05 – 20:25 | Rosemary Akhurst (UCSF, USA) Targeting TGFB signaling in cancer |
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| 20:25 – 20:35 | Short talk 11 Stephen White (University of Pittsburgh, USA) Investigations into the function of the parasitic TGF-β mimic TGM6 |
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| 20:35 – 20:45 | Short talk 12 Emilie Brule (McGill University, Canada) Discovery and characterization of a novel inhibin B co-receptor |
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| 20:45 – 21:00 | Live Q&A Panel Discussion | |
| 21:00 – 21:10 | Awards Ceremony – Best Poster and Best Short Talk Cathy Savage-Dunn and Tom Thompson |
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| 21:10 – 21:20 | Closing Remarks from Conference Chair Gareth Inman End of Conference |
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