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Agenda
All times are listed based on Eastern Time (ET). (Please note: The schedule is subject to change.)All presentations are mostly pre-recorded and followed by live Q&A.
Tuesday, July 13, 2021
| Time | Title/Topic Event |
| 8:30 AM - 8:45 AM | Welcome Address: 20th Anniversary of the Lysophospholipid and Related Mediators FASEB SRC Conference Organizers: Susan Schwab / New York University, USA and Olivier Peyruchaud / INSERM, France Conference Co-organizers: Satoshi Ishii / Akita University, Japan Eric Camerer / INSERM, France |
| 8:45 AM – 9:15 AM |
Keynote Speaker I Timothy Hla (Harvard University, USA) S1P: The well-tempered lysolipid Moderators: Susan Schwab and Eric Camerer |
| 9:15 AM – 9:30 AM | Live Q&A with the Keynote |
| 9:30 AM - 11:55 AM | Session I: Lysophospholipids in cardiovascular biology Session Chairs: Julie Saba and Christina Christoffersen |
| 9:30 AM – 9:50 AM | Susan Smyth (University of Kentucky, USA) Lysophosphatidic acid signaling in cardiovascular diseases |
| 9:50 AM - 10:10 AM | Keisuke Yanagida (National Center for Global Health and Medicine, Japan) S1P-dependent transcriptional switch between physiological and pathological angiogenesis |
| 10:10 AM – 10:20 AM | Short Talk 1 Andrew Kuo (Boston Children's Hospital, USA) De Novo Sphingolipid Synthesis by Endothelial cells is Critical for Sphingolipid Homeostasis In Circulation and Retinal Angiogenesis |
| 10:20 AM – 10:35 AM | Live Q&A |
| 10:35 AM – 10:55 AM | Annarita di Lorenzo (Weill Cornell Medical College, USA) Endothelial sphingolipid regulation in health and disease |
| 10:55 AM – 11:15 AM | R Sathish Srinivasan (Oklahoma Medical Research Foundation, USA) Role of S1PR1 in shear stress-regulated lymphatic vascular patterning |
| 11:15 AM – 11:25 AM | Short Talk 2 Ilaria Del Gaudio (Weill Cornell Medical College/Paris Cardiovascular Research Center) Endothelial Spns2 regulation of vascular tone and blood pressure via sphingosine-1-phosphate |
| 11:25 AM – 11:35 AM | Short Talk 3 Lisa Wilsbacher (Northwestern University Feinberg School of Medicine, USA) Deletion of Sphingosine 1-Phosphate Receptor 1 in cardiomyocytes during development leads to abnormal ventricular conduction and fibrosis |
| 11:35 AM – 11:55 PM | Live Q&A |
| 11:55 AM - 12:15 PM | Break |
| 12:15 PM – 1:00 PM | Career Development Session: Annarita Di Lorenzo; Marianne Martinic; Satoshi Ishii; Olivier Peyruchard Moderator: Olivier Peyruchard and Satoshi Ishii |
| 1:00 PM – 3:10 PM | Session II: Lysophospholipid chaperones and biomarkers Session Chairs: Annarita di Lorenzo and Kevin Lynch |
| 1:00 PM – 1:20 PM | Christina Christoffersen (University of Copenhagen, Denmark) ApoM/S1P and its impact on triglyceride metabolism |
| 1:20 PM – 1:40 PM | Markus Gräler (University Hospital Jena, Germany) S1P-driven adaptive mechanisms in Covid-19 patients |
| 1:40 PM – 1:50 PM | Short Talk 4 Ali Javaheri (Washington University School of Medicine, USA) Apolipoprotein M regulates myocardial autophagy and promotes heart failure survival |
| 1:50 PM – 2:05 PM | Live Q&A |
| 2:05 PM – 2:25 PM | Mette Mathiesen Janiurek (University of Copenhagen, Denmark) APOM/S1M signaling maintains low levels of adsorptive-mediated transcytosis across the blood-brain barrier |
| 2:25 PM – 2:45 PM | Zhongwei Cao (Icahn School of Medicine at Mount Sinai, USA) Aging reprograms S1P signaling in the vascular niche to suppress regeneration and promote fibrosis |
| 2:45 PM – 2:55 PM | Short Talk 5 Kuniyuki Kano (The University of Tokyo, Japan) A simple and optimal plasma preparation method for precise quantification of lysophoshatidic acid |
| 2:55 PM – 3:10 PM | Live Q&A |
| 3:10 PM – 3:30 PM | Break |
| 3:30 PM - 5:50 PM | Session III: Lysophospholipids in immunology and inflammation Session Chairs: Susan Schwab and Jerold Chun |
| 3:30 PM – 3:50 PM | Junken Aoki (University of Tokyo, Japan) Roles of lysophosphatidylserine signaling in regulating immune responses |
| 3:50 PM – 4:10 PM | Raul Torres (University of Colorado, USA) Lysophosphatidic acid regulation of CD8 T cell antigen receptor signaling and immunity |
| 4:10 PM – 4:20 PM | Short Talk 6 Bisera Stepanovska-Tanturovska (University of Bern, Switzerland) Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice. |
| 4:20 PM – 4:35 PM | Live Q&A |
| 4:35 PM – 4:55 PM | Audrey Baeyens (New York University, USA) Monocyte-derived S1P in the lymph node regulates immune responses |
| 4:55 PM – 5:15 PM | Leyre Brizuela (Claude Bernard University, France) Sphingosine 1-phosphate signaling, inflammation and spondyloarthritis |
| 5:15 PM – 5:35 PM | Szandor Simmons (Charité Universitätsmedizin Berlin, Germany) High endothelial cell-derived sphingosine-1-phosphate regulates dendritic cell localization and vascular integrity in the lymph node |
| 5:35 PM – 5:45 PM | Short Talk 7 Zelei Yang (University of Alberta, Canada) Enhanced Breast Tumor Infection with Human Cytomegalovirus through Fibroblasts and PDGFRα facilitates Metastasis-Inducing Inflammation |
| 5:45 PM - 6:05 PM | Live Q&A |
| 6:05 PM - 6:15 PM | Conclusion - End of Day I |
Wednesday, July 14, 2021
| Time | Title/Topic Event |
| 8:30 AM – 8:40 AM | Welcome to Day II Olivier Peyruchaud / INSERM, France Satoshi Ishii / Akita University, Japan |
| 8:40 AM – 9:10 AM |
Keynote Speaker II Wouter Moolenaar (The NKI-Netherlands) Lysophosphatidic acid (LPA): from discovery to anti-tumor immunity Moderators: Satoshi Ishii and Olivier Peyruchaud |
| 9:10 AM – 9:25 AM | Live Q&A with the Keynote |
| 9:25 AM - 12:10 PM | Session IV: Lysophospholipids in cancer Session Chairs: Sarah Spiegel and Olivier Peyruchaud |
| 9:25 AM – 9:45 AM | Viswanathan Natarajan (University of Illinois at Chicago, USA) Lysocardiolipin acyltransferase regulates lung cancer proliferation and migration by modulating mitochondrial dynamics |
| 9:45 AM - 10:05 AM | Céline Colacios (Inserm, Toulouse, France) Sphingolipid metabolism in cancer immune surveillance |
| 10:05 AM – 10:25 AM | Andreas Weigert (Goethe-University, Frankfurt, Germany) S1PR4 signaling in tumor-associated inflammation |
| 10:25 AM – 10:40 AM | Live Q&A |
| 10:40 AM – 11:00 AM | Gabor Tigyi (University of Tennessee, USA) The ATX-LPAR5 in the tumor microenvironment |
| 11:00 AM – 11:20 AM | Kazuhito Naka (Hiroshima University, Japan) The lysophospholipid metabolism enzyme Gdpd3 maintains chronic myelogenous leukemia stem cells |
| 11:20 AM – 11:40 AM | Francesca Auciello (Fondazione Santa Lucia, Italy) A stromal autotaxin-LPA signalling axis promotes pancreatic tumor progression |
| 11:40 AM – 11:50 AM | Short Talk 8 Pratibha Malhorta (Curtin University, Australia) Exosomal lysophospholipids play key role in cancer progression |
| 11:50 AM – 12:10 PM | Live Q&A |
| 12:10 PM - 12:30 PM | Break |
| 12:30 PM – 1:30 PM | Meet the Experts Session Julie Saba; Jerold Chun; Richard Proia; Junken Aoki and Gabor Tigyi Moderator: Susan Schwab and Eric Camerer |
| 1:30 PM – 4:10 PM | Session V: Cell biology and biochemistry of lysophospholipids Session Chairs: Markus Gräler and Junken Aoki |
| 1:30 PM – 1:50 PM | Richard Proia (National Institutes of Health, USA) The itinerary of sphingosine-1-phosphate uptake |
| 1:50 PM – 2:10 PM | Kevin Lynch (University of Virginia, USA) The Pharmacology of S1P Transport Inhibition |
| 2:10 PM – 2:20 PM | Short Talk 9 Long Nguyen (National University of Singapore, Singapore) Mfsd2b and Spns2 coordinate to provide extracellular S1P for development and protection from pathological conditions |
| 2:20 PM – 2:30 PM | Short Talk 10 Taiga Iwama (The University of Tokyo, Japan) Development of an on-tissue derivatization method for MALDI-MS Imaging of LPA and S1P |
| 2:30 PM – 2:50 PM | Live Q&A |
| 2:50 PM – 3:10 PM | Christopher Westlake (National Institutes of Health, USA) Lysophosphatidic acid signaling regulates primary cilium assembly initiation |
| 3:10 PM – 3:30 PM | Elena Pugacheva (West Virginia University School of Medicine, USA) LPA signaling is regulated through the primary cilium: a novel target in glioblastoma |
| 3:30 PM – 3:50 PM | Janis K. Burkhardt (University of Pennsylvania, USA) Lymphocyte egress signal S1P promotes ERM-guided, bleb-based migration |
| 3:50 PM – 4:00 PM | Short Talk 11 Fernando Salgado-Polo (Netherlands Cancer Institute, Netherlands) The role of the Autotaxin tunnel in LPA delivery and its relevance in liver disease |
| 4:00 PM – 4:20 PM | Live Q&A |
| 4:30 PM – 6:00 PM | Poster Session I |
| Conclusion - End of Day II |
Thursday, July 15, 2021
| Time | Title/Topic Event |
| 8:30 AM – 8:40 AM | Welcome to Day III Olivier Peyruchaud / INSERM, France Satoshi Ishii / Akita University, Japan |
| 8:40 AM - 12:05 PM | Session VI: Lysophospholipids: From drug discovery to clinical trials Session Chairs: Timothy Hla and Susan Smyth |
| 8:40 AM – 9:00 AM | Sarah Spiegel (Virginia Commonwealth University, USA) Sphingosine-1-Phosphate: From Bench to Clinic |
| 9:00 AM - 9:20 AM | Hugh Rosen (Scripps Research Institute, San Diego, USA) Mechanisms of S1P modulation of viral cytokine release syndrome |
| 9:20 AM – 9:40 AM | Julie Saba (UC San Francisco, USA) Sphingosine phosphate lyase: From yeast gene to gene therapy |
| 9:40 AM – 9:50 AM | Short Talk 12 Manisha Ray (Sanford Burnham Prebys Medical Discovery Institute, San Diego, USA) Physiologically relevant binding affinity measurements of lysophospholipids using a free-solution, label-free interferometric assay |
| 9:50 AM – 10:00 AM | Short Talk 13 Shintaro Maeda (Kyoto University, Japan) Crystal structure of active sphingosine-1-phosphate receptor 3 |
| 10:00 AM – 10:25 AM | Live Q&A |
| 10:25 AM - 10:45 AM | Fu-Dong Shi (Beijing Tiantan Hospital, China) Modulating brain inflammation: compartment, timing and drug selection |
| 10:45 AM – 11:05 AM | Marianne Martinic (Idorsia Pharmaceuticals, Switzerland) Cenerimod, a novel S1P1 receptor modulator, targets the immunopathology of systemic lupus erythematosus and Sjögren’s Syndrome in two preclinical mouse models |
| 11:05 AM – 11:15 AM | Short Talk 14 Keiko Fukasawa (Ochanomizu University, Tokyo, Japan) Biosynthesis of β-lysophosphatidic acid from cyclic phosphatidic acid by autotaxin, and bioactivity of a novel β-lysophosphatidic acid analogue, 2-carba-lysophosphatidic acid |
| 11:15 AM - 11:25 AM | Short Talk 15 Deepa Jonnalagadda (Sanford Burnham Prebys Medical Discovery Institute, San Diego, USA) Sphingosine 1-phosphate (S1P) inhibits astrocytic glutamate uptake through S1P2-Ga12 signaling |
| 11:25 AM - 11:35 AM | Short Talk 16 Andreane Cartier (Boston Children's Hospital, USA) S1P receptor 1 expression in endothelial cells promotes vascular normalization and antitumor therapies |
| 11:35 AM – 12:00 PM | Live Q&A |
| 12:00 PM – 12:30 PM | Break |
| 12:30 PM – 1:30 PM |
Meet the Experts |
| 1:30 PM – 2:45 PM | Poster Session II |
| 2:45 PM – 5:50 PM | Session VII: Novel aspects of lysophospholid biology Session Chairs: Richard Proia and Zhongwei Cao |
| 2:45 PM – 3:05 PM | Jerold Chun (Sanford Burnham Prebys Medical Discovery Institute, San Diego, USA) Lysophospholipid signaling in brain disorders |
| 3:05 PM – 3:25 PM | Irma Machuca-Gayet (Inserm, Lyon, France) ATX role in bone mass regulation |
| 3:25 PM – 3:45 PM | Dylan Stavish (University of Sheffield, UK) Generation and trapping of a mesoderm biased state of human pluripotency |
| 3:45 PM – 3:55 PM | Short Talk 17 Candide Alioli (INSERM U1033 Lyos, France) LPA1 controls FGF2-mediated osteocyte dendrite network |
| 3:55 PM – 4:15 PM | Live Q&A |
| 4:15 PM – 4:35 PM | Kun-Liang Guan (UC San Diego, USA) Mechanism of the Hippo pathway regulation and its role in cancer |
| 4:35 PM – 4:55 PM | Dolly Mehta (University of Illinois, USA) Programming to S1PR1+ Endothelial Cells Promote Restoration of Vascular Integrity |
| 4:55 PM – 5:05 PM | Short Talk 18 Yugo Takagi (The University of Tokyo, Japan) Search for novel oxidized phospholipid receptor involved in pruritic skin disease and its functional analysis |
| 5:05 PM – 5:15 PM | Short Talk 19 Long Chung (The Centenary Institute, Australia) Role of sphingosine 1-phosphate in mitochondrial biology and metabolic disorders in the liver |
| 5:15 PM – 5:25 PM | Short Talk 20 Uranbileg Baasanjav (The University of Tokyo, Japan) Involvement of SPL in the pathogenesis of cancer through converting sphingolipids to glycerophospholipids |
| 5:25 PM - 5:50 PM | Live Q&A |
| 5:50 PM – 6:00 PM | Final Remarks and Conclusion - End of Conference |
