Program agenda is subject to change.

Sunday, December 5, 2021

Time	Event
4:00 pm – 9:00 pm	Conference Registration
6:00 pm – 7:00 pm	Organizer's Welcome Reception
7:00 pm – 8:00 pm	Dinner
8:00 pm – 8:15 pm	Welcome and Introductions Dario Vignali, PhD (University of Pittsburgh)
8:15 pm – 9:15 pm	Opening Keynote Lecture Jane Buckner, MD (Benaroya Research Institute) Therapeutic Interventions: What they teach about immune pathways and disease heterogeneity

 

Monday, December 6, 2021

Time	Event
7:30 am – 12:00 pm	Conference Registration
7:30 am – 9:00 am	Breakfast
9:00 am – 12:00 pm	Session 1: Molecular mechanisms and systems biology in autoimmunity Chair: Marcus Clark, MD (University of Chicago)
9:00 am – 9:30 am	David Hafler, MD (Yale School of Medicine) A Transcriptional Mechanism for Foxp3+ Regulatory T cell Dysfunction in Autoimmune Diseases
9:30 am – 10:00 am	Golnaz Vahedi, PhD (University of Pennsylvania) Defining how 3D genome organization controls T cell function
10:00 am – 10:15 am	Short Talk Speaker
10:15 am – 10:45 am	Coffee Break
10:45 am – 11:00 am	Short Talk Speaker
11:00 am – 11:30 am	Montserrat Anguera, PhD (University of Pennsylvania) X-chromosome inactivation perturbation in lupus
11:30 am – 12:00 pm	Invited Speaker - TBA
12:00 pm – 1:00 pm	Lunch
1:00 pm – 4:00 pm	Free Time
4:00 pm – 6:00 pm	Poster Session
6:00 pm – 7:00 pm	Dinner
7:00 pm – 8:45 pm	Session 2: Innate and neuronal impact on immune mechanisms Chair: Alessandra Pernis, MD (Hospital for Special Surgery, NYC)
7:00 pm – 7:30 pm	Carla Rothlin, PhD (Yale University) Cytokine induced hysteresis in naïve T cell activation
7:30 pm – 8:00 pm	Jessica Hamerman, PhD (Benaroya Research Institute)  The role of IgA in immune complex activation of pDCs in lupus
8:00 pm – 8:15 pm	Short Talk Speaker
8:15 pm – 8:45 pm	Dan Kaplan, MD, PhD (University of Pittsburgh) Neuronal control of cutaneous inflammation
8:45 pm – 10:30 pm	Networking and Social Time

 

Tuesday, December 7, 2021

Time	Event
7:30 am – 12:00 pm	Conference Registration
7:30 am – 9:00 am	Breakfast
9:00 am – 12:00 pm	Session 3: Impact of the microbiome and environment on autoimmunity Chair: Mark Shlomchik, MD, PhD (University of Pittsburgh)
9:00 am – 9:30 am	Gianna Hammer, PhD (Duke University) Environmental cues for inflammatory T cell responses
9:30 am – 10:00 am	TBD  Modulation of neuroinflammation by microbial-mucosal interactions
10:00 am – 10:15 am	Short Talk Speaker
10:15 am – 10:45 am	Coffee Break
10:45 am – 11:00 am	Short Talk Speaker
11:00 am – 11:30 am	Rachel Caspi, PhD (NIH) Autoimmune triggers at immune privileged sites
11:30 am – 12:00 pm	Kevin Herold, MD (Yale School of Medicine)             Immune/beta cell interactions and Type 1 diabetes
12:00 pm – 1:00 pm	Lunch/Meet the Experts
1:00 pm – 4:00 pm	Free Time
4:00 pm – 6:00 pm	Poster Session
6:00 pm – 7:00 pm	Dinner
7:00 pm – 8:45 pm	Session 4: Immune regulation in autoimmunity Chair: Avery August, PhD (Cornell University)
7:00 pm – 7:30 pm	Dario Vignali, PhD (University of Pittsburgh) Regulatory T cell insufficiency as a driver of autoimmune disease
7:30 pm – 8:00 pm	Maria Bettini, PhD (University of Utah) T cell receptor parameters of regulatory T cell function in autoimmunity
8:00 pm – 8:15 pm	Short Talk Speaker
8:15 pm – 8:45 pm	Invited Speaker - TBA
8:45 pm – 10:30 pm	Networking and Social Time

 

Wednesday, December 8, 2021

Time	Event
7:30 am – 12:30 pm	Conference Registration
7:30 am – 9:00 am	Breakfast
9:00 am – 12:30 pm	Session 5: Autoreactive T cells Chair: Carla Rothlin (Yale School of Medicine)
9:00 am – 9:30 am	Joan Goverman, PhD (University of Washington) The Paradoxical Role of IFN gamma in CNS Autoimmunity
9:30 am – 10:00 am	Terri Laufer, MD (University of Pennsylvania) DC-TFH crosstalk
10:00 am – 10:15 am	Short Talk Speaker
10:15 am – 10:45 am	Coffee Break
10:45 am – 11:00 am	Short Talk Speaker
11:00 am – 11:30 am	Joseph Larkin III, PhD (University of Florida) Regulation of autoimmune t lymphocyte effector functions by a peptide mimetic of suppressor of cytokine signaling-1
11:30 am – 12:00 pm	Avery August, PhD (Cornell University) Regulation of Th17-Treg balance during inflammation
12:00 pm – 12:30 pm	Business Meeting
12:30 pm – 1:30 pm	Lunch
1:30 pm – 2:30 pm	Career Development Session
2:30 pm – 6:00 pm	Free Time
6:00 pm – 7:00 pm	Dinner
7:00 pm – 8:45 pm	Session 6: B cells in autoimmunity Chair: Montserrat Anguera, PhD (University of Pennsylvania)
7:00 pm – 7:30 pm	Mark Shlomchik, MD, PhD (University of Pittsburgh) Extrafollicular “Non-Canonical” B Cell Responses: Mechanisms and Implications for Immunity and Autoimmunity
7:30 pm – 8:00 pm	Alessandra Pernis, MD (Hospital for Special Surgery, NYC) Molecular mechanisms controlling B cells in immunity and autoimmunity
8:00 pm – 8:15 pm	Short Talk Speaker
8:15 pm – 8:45 pm	Marcus Clark, MD (University of Chicago) In situ immune cell architectures in lupus nephritis
8:45 pm – 10:30 pm	Networking and Social Time

 

Thursday, December 9, 2021

Time	Event
7:30 am – 12:00 pm	Conference Registration
7:30 am – 9:00 am	Breakfast
9:00 am – 12:00 pm	Session 7: Clinical developments in the treatment of autoimmune disease Chair: Rachel Caspi, PhD (NIH)
9:00 am – 9:30 am	Megan Levings, PhD (University of British Columbia, Vancouver) Development of Treg cell therapies for autoimmunity and transplantation
9:30 am – 10:00 am	Jodi Karnell, PhD (Horizon Therapeutics) HZN-7734 depletes plasmacytoid dendritic cells and reduces the type I IFN response in cutaneous lupus
10:00 am – 10:15 am	Short Talk Speaker
10:15 am – 10:45 am	Coffee break
10:45 am – 11:00 am	Short Talk Speaker
11:00 am – 11:30 am	Dan Cua (Janssen) IL-23 immune axis in skin, joint, and gut chronic inflammatory diseases
11:30 am – 12:00 pm	Salam Shaaban, PhD (Rubius Therapeutics) T1D treatment
12:00 pm – 1:00 pm	Lunch
1:00 pm – 2:00 pm	Session 8: Novel, emerging treatments for autoimmunity Chair: Terri Laufer, MD (University of Pennsylvania)
1:15 pm – 2:15 pm	Closing Keynote Lecture Vijay Kuchroo, PhD (Harvard University) Single cell clonotype tracing of pathogenic Th17cells and their stem-like precursors
2:15 pm – 2:30 pm	Closing Remarks