Agenda

Please note that this is a tentative agenda. Most talks will be pre-recorded with live question/answer periods. All times presented are in Eastern Daylight Time (EDT). 


Wednesday June 30, 2021
 
 Time – EDT Time  Event – The Protein Lipidation Conference
 08:30 am – 08:45 am  Conference Opens - Welcome Day I
 Organizers: James Hougland, Paul Jenkins, and Mei Wang
 08:45 am – 09:15 am Keynote Lecture: Dr. Martin Bergö (Karolinska Institute)
Defining the Efficacy of Targeting ICMT in Cancer and Progeria
Moderator: James Hougland
 09:15 am – 09:30 am  Live Q&A with the Keynote Speaker
 Moderator: James Hougland
 09:30 am – 09:45 am  Break
 9:45 am – 12:00 pm Session 1: DRUG DISCOVERY AND CHEMICAL TOOLS FOR STUDYING PROTEIN LIPIDATION
Session Chair: Mei Wang
 09:45 am – 10:05 am  Ed Tate, Drugging protein lipidation
 10:05 am – 10:25 am  Dolores Di VizioHigh-throughput palmitoyl-proteomics profiling  of prostate cancer-derived extracellular vesicles
 10:25 am – 10:40 am Short Talk 1: Saara-Anne Azizi, An acrylamide-based inhibitor of DHHC family proteins to probe ERK1/2 acylation
 10:40 am – 10:55 am  Live Q&A Panel Discussion
 10:55 am - 11:15 am  Luc BerthiaumeN-myristoyltransferase inhibitors for lymphoma and leukemia: our journey to clinical trials
 11:15 am – 11:30 am Short Talk 2: Javier Valdez-Taubas, A novel yeast-based high-throughput method for the identification of protein palmitoylation inhibitors
 11:30 am – 11:45 am Short Talk 3: Cory (Tony) Ocasio, ZDHHC chemical genetics reveals novel S-acylation-linked biology
 11:45 am – 12:00 pm  Live Q&A Panel Discussion
 12:00 pm – 12:15 pm  Break
 12:15 pm – 1:15 pm Meet the Experts
Greg Fairn; Carol Williams; Anirban Banerjee; Carmela Giglione; Liz Conibear
Moderator: James Hougland
 1:15 pm - 3:30 pm  Session 2: PROTEIN LIPIDATION IN IMMUNOLOGY, SIGNALING, AND   DISEASE
 Session Chair: Paul Jenkins
 1:15 pm – 1:35 pm  Donghai Wang, Role of Protein Geranylgeranylation in Anti-viral Innate Immune Response
 1:35 pm – 1:55 pm  Shernaz Bamji, Palmitoylating Enzymes in Brain Development and Disease
 1:55 pm – 2:10 pm Short Talk 4: Julie Gupta, Ankyrin-B is lipid-modified by S-palmitoylation to promote dendritic membrane scaffolding of voltage gated sodium channel Nav1.2 in neurons
 2:10 pm – 2:25 pm  Live Q&A Panel Discussion
 2:25 pm – 2:45 pm  Rejji Kuruvilla, Compartmentalized protein synthesis and lipidation in axon growth
 2:45 pm – 3:00 pm Short Talk 5: Caglar Gok, Insulin mediated palmitoylation in NCX1 function
 3:00 pm – 3:15 pm Short Talk 6: Rocio Hollman, The palmitoylating enzyme, zDHHC9, in intellectual disability
 3:15 pm – 3:30 pm  Live Q&A Panel Discussion
 3:35 pm – 5:00 pm  Poster Session 1
 5:00 pm – 5:15 pm  Conclusion - End of Day I

Thursday July 1, 2021
 
 Time - EDT  Event – The Protein Lipidation Conference
 08:30 am – 08:45 am  Day 2 Welcome Address
 08:45 am – 09:15 am  Keynote Lecture: Dr. Gisou van der Goot (EPFL)
 
Palmitoylation of SARS-CoV2
 Moderator: James Hougland
 09:15 am – 09:30 am Live Q&A with the Keynote Speaker
Moderator: James Hougland
 09:30 am – 09:45 am  Break
 9:45 am – 12:00 pm  Session 3: STRUCTURAL BIOLOGY OF PROTEIN LIPIDATION
Session Chair: Bryan Dickinson
 09:45 am – 10:05 am  Anirban Banerjee, Bivalent recognition of a fatty acyl CoA by a DHHC enzyme
 10:05 am – 10:25 am  Angeline Lyon, Regulation of Phospholipase C epsilon by Small GTPases
 10:25 am – 10:40 am Short Talk 7: George Zheng, Discovery of lysine isobutyrylation as a new histone modification mark
 10:40 am – 10:55 am  Live Q&A Panel Discussion
 10:55 am - 11:15 am  Laura Burrus, Wnt palmit(e)oylation: A ticket to ride
 11:15 am – 11:30 am Short Talk 8: Jacob Moose, Virtual screening and a continuous acylation assay enables discovery of new GOAT inhibitors
 11:30 am – 11:45 am Short Talk 9: Laurence Abrami, Palmitoylated acyl protein thioesterase LYPLA2 deforms membranes to extract substrate acyl chains
 11:45 am – 12:00 pm  Live Q&A Panel Discussion
 12:00 pm – 12:15 pm  Break
 12:15 pm – 1:00 pm Career Development Session
Jennifer Greaves; Gareth Thomas; Jeff Johnson; Shaun Sanders; Maurine Linder
Moderator: Paul Jenkins
 1:00 pm – 1:15 pm  Break
 1:15 pm – 2:30 pm  Poster Session 2
 2:30 pm – 4:00 pm  Session 4: ENZYMOLOGY OF LIPIDATION
 Session Chair: Christian Siebold
 2:30 pm – 2:50 pm  Marilyn Resh, Fatty Acylation of Hedgehog and Wnt proteins
 2:50 pm – 3:10 pm  Jennifer Greaves, Novel acyl protein thioesterases regulate dynamic S-acylation of the SNARE protein SNAP25
 3:10 pm – 3:25 pm Short Talk 10: Sydney Holme, N-terminal domain of the ABHD17 proteins regulates activity on NRas
 3:25 pm – 3:40 pm Short Talk 11: Alison Ondrus, Small molecule inhibitors of Hedgehog oncoproteins
 3:40 pm – 4:00 pm  Live Q&A Panel Discussion
 4:00 pm – 4:15 pm  Break
 4:15 pm – 5:45 pm  Session 5:  NEW FRONTIERS IN PROTEIN LIPIDATION
 Session Chair: Shernaz Bamji
 4:15 pm – 4:35 pm  Davoud MozhdehiGenetically encoded lipidation to manipulate the structure, assembly, and phase behavior of proteins
 4:35 pm – 4:55 pm  Shafi Kuchay, Lipids and lipid-bound chaperone control compartmental protein   targeting via ubiquitin proteasome system
 4:55 pm – 5:10 pm Short Talk 12: Mira Androniciuc, Modulating the Wnt Pathway through Lipid-dependent Interactions
 5:10 pm – 5:25 pm Short Talk 13: John Sanderson, Protein lipidation By uncatalyzed acyl transfer from lipids: Fact or fantasy?
 5:25 pm – 5:45 pm  Live Q&A Panel Discussion
 5:45 pm – 6:00 pm  Conference Wrap up by Organizers and Conclusion of the Conference