Agenda

All times listed are Eastern Daylight Time.

All talks will be mainly pre-recorded with live question/answer periods. Please note that the agenda is subject to change.

Tuesday, June 22, 2021
Time Title/Topic Event
8:30 - 8:45 AM Conference Opens – Welcome
Organizer: Tom Rutkowski
Co-organizer: Carolyn Sevier
8:45 -10:00 AM
 		 EMBO Keynote Lecture
Jonathan Weissman
Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients
10:00 -10:15 AM Live Q&A with the Keynote
10:15 -11:55 AM Session I: Translational Approaches
Moderators: Pedro Carvalho and Xi Chen
10:15 – 10:35 AM Speaker 1: Fumihiko Urano
Endoplasmic Reticulum: A Primary Therapeutic Target for Wolfram syndrome, Diabetes, and Retinal Degeneration
10:35 - 10:55 AM Speaker 2: Anne Bertolotti
eIF2 phosphorylation: Ups and downs
10:55 – 11:15 AM Speaker 3: Luke Wiseman
Pharmacologic Targeting of the Unfolded Protein Response
11:15 – 11:35 AM Speaker 4: Chris Wooddell
RNAi therapeutic to prevent and reverse ER accumulation of Z-alpha-1 antitrypsin
11:35 – 11:55 AM Live Q&A
11:55 - 12:15 PM Break
12:15 – 1:15 PM Meet the Experts:
Luke Wiseman, Xi Chen, Susan Fink, and Anne Bertolotti 
Moderator: Tom Rutkowski
1:15 - 2:15 PM Poster Session 1
2:15 – 5:10 PM Session II: ER Biogenesis
Moderators: Susan Ferro-Novick and Abby Buchwalter
2:15 – 2:35 PM Speaker 1: Chris Nicchitta
RNA Localization and Translation on the ER: Models and Mechanisms
2:35 – 2:55 PM Speaker 2: Susan Shao
Structural insights into metazoan pre-targeting GET complexes
2:55 – 3:05 PM Short Talk 1
Smita Yadav
An ER Kinase that Catalyzes the Dynamic Tethering of ER to Microtubules
3:05 – 3:15 PM Short Talk 2
Ahmad Jomaa
Mechanism of co-translational nascent chain sorting and targeting to the endoplasmic reticulum by NAC and SRP
3:15 - 3:35 PM Live Q&A
3:35 - 3:55 PM Speaker 3: Robert Keenan
An ER translocon for multi-pass membrane protein biogenesis
3:55 – 4:15 PM Speaker 4: Shu-ou Shan
Fidelity of cotranslational protein targeting to the ER
4:15 – 4:25 PM Short Talk 3
Jacob Culver
Deubiquitinases USP20/33 promote the biogenesis of tail-anchored membrane proteins
4:25 - 4:35 PM Short Talk 4
Elena Ivanova
Dissecting protein localization signals with deep mutational scanning
4:35 - 4:45 PM Short Talk 5
Haddas Saad
Protein dynamics from the ER to the ERQC and back
4:45 – 5:10 PM Live Q&A
5:10 - 5:20 PM Conclusion - End of Day One
 
Wednesday, June 23, 2021
Time Title/Topic Event
8:30 - 8:40 AM Conference Opens – Welcome Day 2
Organizer: Tom Rutkowski
8:40 -12:05 PM Session III: ER Quality Control
Moderators: Liz Miller and Guillaume Thibault
8:40 – 9:00 AM Speaker 1: Kaz Nagata
Quality control of procollagen in the ER by collagen-specific molecular chaperone Hsp47
9:00 - 9:20 AM Speaker 2: Linda Hendershot
Mapping BiP co-chaperone binding sequences in Surfactant Protein C provides insights into BRICHOS domain function and disease-associated mutations
9:20 – 9:40 AM Speaker 3: Pedro Carvalho
Quality control of membrane proteins at the ER
9:40 - 10:00 AM Speaker 4: Ineke Braakman
Intramolecular quality control
10:00 – 10:20 AM Live Q&A
10:20 – 10:40 AM Speaker 5: James Olzmann
Lipid droplet proteome remodeling and ER-associated degradation
10:40 – 11:00 AM Speaker 6: Jeff Brodsky
Choosing your poison: The targeting of misfolded proteins for ERAD versus post-ER degradation
11:00 – 11:20 AM Speaker 7: Sonya Neal
Rhomboid pseudo amprotease Dfm1 ERADicates multi-spanning membrane substrates from the ER
11:20 – 11:30 AM Short Talk 6
Prasanna Satpute-Krishnan
Competition for calnexin binding regulates the turnover of misfolded GPI-anchored proteins
11:30 – 11:40 AM Short Talk 7
Ilaria Fregno
N-glycan processing dictates proteasomal or lysosomal clearance of misfolded proteins from the ER
11:40 – 12:05 PM Live Q&A
12:05 – 12:30 PM Break
12:30 – 1:45 PM Career Development Session
Job paths outside postdoc-to-research university PI?
Moderator: Carolyn Sevier
Participants:
Will Prinz
Chris Wooddell
VJ Rubenstein
1:45 - 2:45 PM Poster Session 2
2:45 – 4:55 PM Session IV: Organelle Communication
Moderators: Linda Hendershot and Lars Plate
2:45 – 3:05 PM Speaker 1: Liz Miller
A biophysical basis for sorting stringency into COPII vesicles
3:05 – 3:25 PM Speaker 2: William Prinz
Contact sites and GPI anchor synthesis
3:25 – 3:35 PM Short Talk 8
Tino Pleiner
WNK1 is an assembly factor for the human ER membrane protein complex
3:35 – 3:50 PM Live Q&A
3:50 – 4:10 PM Speaker 3: Gyuri Hajnoczky
ER-mitochondrial contacts and local signaling by Ca2+ and ROS
4:10 – 4:30 PM Speaker 4: Susan Ferro-Novick
A role for a COPII coat subunit in ER autophagy
4:30 – 4:40 PM               Short Talk 9
Ilaria Sorrentino
A redox ER-mitochondria crosstalk sustains oxidative folding
4:40 – 4:55 PM Live Q&A
4:55 - 5:15 PM Conclusion - End of Day Two
 
Thursday, June 24, 2021
Time Title/Topic Event
8:30 - 8:40 AM Conference Opens – Welcome Day 3
Organizer: Tom Rutkowski
8:40 - 12:25 PM Session V: Metabolic and Infectious Diseases
Moderators: James Olzmann and Susan Shao
8:40 – 9:00 AM Speaker 1: Billy Tsai
How ER-phagy degrades mutant proinsulins to rectify a diabetic syndrome
9:00 - 9:20 AM Speaker 2: Susan Fink
Unfolding the roles of ER stress in viral infection
9:20 – 9:40 AM Speaker 3: Ying Maggie Chen
Endoplasmic Reticulum Dyshomeostasis and Kidney Disease
9:40 – 9:50 AM Short Talk 10
Chien-Wen Chen
Adaptive reprogramming of pancreatic beta-cells to chronic ER stress
9:50 – 10:00 AM Short Talk 11
Mariska Simpson
IRE1a directly binds the cholera toxin subdomain A1
10:00 – 10:25 AM Live Q&A
10:25 – 10:40 AM Break
10:40 – 11:00 AM Speaker 4: Gisou van der Gout
Palmitoylation in SARS-CoV biogenesis in the early secretory pathway
11:00 – 11:20 AM Speaker 5: Emilyn Alejandro
O-GlcNAc signaling, the sweet side regulation of ER stress and insulin processing in pancreatic beta-cells
11:20 – 11:40 AM Speaker 6: Lars Plate
Comparative interactomics of coronavirus nonstructural proteins identifies shared and unique ER-mitochondrial host cell dependencies
11:40 – 11:50 AM Short Talk 12
Rakesh Ganji
Regulation of Endoplasmic Reticulum and Mitochondria contact sites dynamics by p97-UBXD8 complex via lipid metabolism
11:50 – 12:00 PM Short Talk 13
Amit Joshi
Formation of nascent lipid droplets at specialized ER subdomains
12:00 – 12:25 PM Live Q&A
12:25 – 12:40 PM Break
12:40 – 1:40 PM Meet the Experts
Jeff Brodsky, Liz Miller, Susan Ferro-Novick, and Chris Nicchitta
Moderator: Tom Rutkowski
1:40 - 1:50 PM Break
1:50 – 5:05 PM Session VI: UPR Signaling, Cell Fate, and Cancer
Moderators: Carolyn Sevier and Sonya Neal (to be confirmed)
1:50 – 2:10 PM Speaker 1: Rebecca Taylor
Inter-tissue UPR Activation: How Neuronal Signaling Promotes Organismal Resilience
2:10 – 2:30 PM Speaker 2: Randal Kaufman
The UPR transducer ATF6 drives fatty liver disease progression to carcinoma
2:30 – 2:50 PM Speaker 3: Abby Buchwalter
A long strange trip: dynamic trafficking of the inner nuclear membrane protein emerin to the lysosome
2:50 – 3:00 PM Short Talk 14
Luke Perera
Post-translational regulation of BiP by FICD-mediated AMPylation and deAMPylation
3:00 – 3:10 PM               Short Talk 15
Weihan Li
Regulating ER protein homeostasis by differentially processing mRNAs
3:10 – 3:35 PM Live Q&A
3:35 – 3:45 PM Break
3:45 – 4:05 PM Speaker 4: Shannon Elf
Characterizing and targeting the unfolded protein response in calreticulin-mutated myeloproliferative neoplasms
4:05 – 4:25 PM Speaker 5: Xi Chen
Targeting the Unfolded Protein Response to reverse therapy resistance
4:25 – 4:35 PM Short Talk 16
Ojore Oka
Activation of the UPR sensor ATF6 is regulated by its redox-dependent dimerisation
4:35 – 4:45 PM Short Talk 17
Thorsten Hoppe
ER Quality Control Is Mediated by ER-Associated RNA Silencing (ERAS)
4:45 – 5:05 PM Live Q&A
5:05 - 5:30 PM Conclusion - End of Day Three
Organizer: Tom Rutkowski
Co-organizer: Carolyn Sevier