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Agenda
The Microbial Pathogenesis Conference: Mechanisms of Infectious Disease
Please note that all times listed currently reflect US Central Time (CT). The schedule is subject to change.
Presentations are live or pre-recorded followed by live Q&A
Tuesday, July 13th, 2021
| Time | Event |
| 8:30 am – 8:45 am | Day One Welcome and Introductions: Kim Orth (UT Southwestern Medical Center) & Ken Campellone (University of Connecticut) |
| 8:45 am – 9:30 am | Keynote Address: Andrew Camilli (Tufts University) Fields Lecture The Varied Impact of Phages on Cholera |
| 9:30 am – 9:45 am | Questions and Answers |
| 9:45 am – 12:00 pm | Session 1: Pathogens and Disease Chair: Kim Orth (UT Southwestern Medical Center) |
| 9:45 am – 10:10 am | Raphael Valdivia (Duke University) Genetics and genomics basis for host colonization and mucin metabolism by the beneficial gut microbe Akkermansia muciniphila |
| 10:10 am – 10:35 am | Dor Salomon (Tel Aviv University) Activation of inflammasome-mediated cell death by a Vibrio T6SS |
| 10:35 am – 11:00 am | Mariana Byndloss (Vanderbilt University) Microbiota-derived aspartate drives Salmonella expansion during colitis |
| 11:00 am – 11:25 am | Kat Milligan-Myhre (University of Connecticut) Host environment, microbiota, and potential pathogen interactions |
| 11:25 am – 11:40 am | Short Talk: Katrina Velle (University of Massachusetts, Amherst) Actin dynamics drive pathogenic behaviors in a relative of the "brain-eating amoeba" |
| 11:40 am – 11:55 am | Short Talk: Krystal Ching (NYU School of Medicine) Autophagy mediated mechanisms of protection against SARS-CoV-2 |
| 11:55 am – 1:15 pm | Break |
| 12:15 pm – 1:00 pm | Meet the Experts Session 1 - Breakout rooms for Keynotes 1&2, Sessions 1,2,3 Speakers |
| 1:15 pm – 3:30 pm | Session 2: Structural Biology and Pathogens Chair: Ken Campellone (University of Connecticut) |
| 1:15 pm – 1:40 pm | Vinnie Tagliabracci (UTSW) Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases |
| 1:40 pm – 2:05 pm | Mimi Ho (Columbia University) Structural parasitology of the Malaria Parasite Plasmodium falciparum |
| 2:05 pm – 2:30 pm | Leah Cowen (University of Toronto) Structure-guided Approaches to Develop Antifungals to Cripple Drug-resistant Fungal Pathogens |
| 2:30 pm – 2:55 pm | Gaya Amarasinghe (Washington University) Enter, hide, and detect: molecular mechanisms at the host-viral interface |
| 2:55 pm – 3:10 pm | Short Talk: Karan Kaval (University of Texas Southwestern Medical Center) Transertion: Localization, Expression and Assembly of the V. parahaemolyticus T3SS2 |
| 3:10 pm – 3:25 pm | Short Talk: Erin Green (Vanderbilt University Medical Center) A bacterial dehydrin promotes pathogen desiccation tolerance |
| 3:25 pm – 3:45 pm | Break |
| 3:45 pm – 5:00 pm | Poster Session 1 - Posters will be available online for viewing a few days prior to the virtual SRC; session time will be devoted to Q&A between poster presenters and attendees |
| 5:00 pm – 6:00 pm | Happy Hour |
Wednesday, July 14th, 2021
| Time | Event |
| 8:30 am – 8:45 am | Day Two: Welcome Address and Summary of Day One |
| 8:45 am – 9:30 am | Keynote Address: Andrea Carfi (Moderna) Development of the Moderna COVID-19 Vaccine (mRNA-1273) and Preparing for Variants of Concern |
| 9:30 am – 9:45 am | Questions and Answers |
| 9:45 am – 12:00 pm | Session 3: Anti-Microbial Drug Discovery Chair: Kim Orth (UT Southwestern Medical Center) |
| 9:45 am – 10:10 am | Anita Sil (University of California at San Francisco) Regulation of cell shape and virulence factor expression in response to temperature in the fungal pathogen Histoplasma capsulatum |
| 10:10 am – 10:35 am | Michael Lorenz (UTHSC) A 12 amino acid peptide derived from Enterococcus EntV is an antivirulence agent against Candida albicans |
| 10:35 am – 11:00 am | Elizabeth Winzeler (University of California at San Diego) Discovering targets for eukaryotic pathogens: tales from two phyla |
| 11:00 am – 11:25 am | Steve Rutherford (Genentech) Inhibiting BamA to understand outer membrane protein folding |
| 11:25 am – 11:40 am | Short Talk: Shelby Priest (Duke University) Rampant transposition and loss of RNAi cause hypermutation and antifungal drug resistance in Cryptococcus neoformans |
| 11:40 am – 11:55 am | Short Talk: Richard Lavin (Tufts University) Targeting Mycobacterium tuberculosis environmental cue response for the development of antitubercular drugs |
| 11:55 am – 1:15 pm | Break |
| 12:15 pm – 1:00 pm | Meet the Expert Session 2 - Breakout rooms for Keynote 3, Sessions 4,5,6 Speakers |
| 1:15 pm – 2:30 pm | Poster Session 2 - Posters will be available online for viewing a few days prior to the virtual SRC; session time will be devoted to Q&A between poster presenters and attendees |
| 2:30 pm – 2:45 pm | Break |
| 2:45 pm – 5:00 pm | Session 4: Health and Metabolism for Pathogens Chair: Ken Campellone (University of Connecticut) |
| 2:45 pm – 3:10 pm | Heran Darwin (New York University) Aldehydes: An Achilles' Heel for Mycobacterium tuberculosis |
| 3:10 pm – 3:35 pm | Ileana Cristea (Princeton University) Virus regulation of mitochondrial structure and bioenergetics viewed through the lens of proteomics |
| 3:35 pm – 4:00 pm | Michael Fischbach (Stanford University) Inducing antigen-specific T cells with engineered commensals |
| 4:00 pm – 4:25 pm | Vernon Carruthers (University of Michigan) Toxoplasma autophagy and persistence of a pervasive brain parasite |
| 4:25 pm – 4:40 pm | Short Talk: Kayla Sylvester (Duke University) Characterization of the tubovesicular network in Plasmodium vivax liver stage hypnozoites and schizonts |
| 4:40 pm – 4:55 pm | Short Talk: Audrey Chong (Laboratory of Bacteriology, Rocky Mountain Labs, NIAID, NIH) Cytosolic replication in epithelial cells fuels intestinal expansion and chronic fecal shedding of Salmonella Typhimurium |
Thursday, July 15th, 2021
| Time | Event |
| 8:30 am – 8:45 am | Day Three: Welcome Address and Summary of Day Two |
| 8:45 am – 9:30 am | Keynote Address: Dominique Soldati-Favre (University of Geneva) Metabolic needs and capabilities of Toxoplasma gondii during acute and chronic infection |
| 9:30 am – 9:45 am | Questions and Answers |
| 9:45 am – 12:00 pm | Session 5: Host-Pathogen Interactions Chair: Kim Orth (UT Southwestern Medical Center) |
| 9:45 am – 10:10 am | Carolyn Coyne (Duke University) Antimicrobial signaling at the maternal-fetal interface |
| 10:10 am – 10:35 am | Shaeri Mukherjee (University of California at San Francisco) How to make a home in the Endoplasmic Reticulum |
| 10:35 am – 11:00 am | Nels Elde (University of Utah) Linking immune responses to virus discovery in zebrafish |
| 11:00 am – 11:25 am | Hiten Madhani (University of California at San Francisco) Manipulation of Macrophage Polarization by a Fungal Meningitis Pathogen |
| 11:25 am – 11:40 am | Short Talk: Brittney Moore (UW School of Medicine and Public Health) Comparison of structural brain imaging in infant macaques with prenatal Zika virus exposure in mid- and late-first trimester |
| 11:40 am – 11:55 am | Short Talk: Minna Ding (University of Minnesota) Defining the criteria for establishing a murine model of latent Cryptococcus neoformans infection using clinical isolates |
| 11:55 am – 1:00 pm | Break |
| 12:00 pm – 12:55 pm | Career Development: Meet Experts with Careers in Science Victoria McGovern (Burroughs Wellcome Fund), Steve Rutherford (Genentech), and Patricia Haggerty (NIH/NIAID) |
| 1:15 pm – 3:25 pm | Session 6: Drugs and Resistance Chair: Ken Campellone (University of Connecticut) |
| 1:15 pm – 1:40 pm | Anna Selmecki (University of Minnesota) High copy number amplifications during adaptation to antifungal drugs |
| 1:40 pm – 2:05 pm | Andreas Baumler (University of California at Davis) Gastrointestinal host-pathogen interaction in the age of microbiome research |
| 2:05 pm – 2:30 pm | Breck Duerkop (University of Colorado) Enterococcal phages and antibiotics dictate polymicrobial interactions |
| 2:30 pm – 2:55 pm | David Roos (University of Pennsylvania) Integrative biology in the Omics era |
| 2:55 pm – 3:10 pm | Short Talk: Kimberly Davis (Johns Hopkins Bloomberg School of Public Health) Subpopulations of stressed Y. pseudotuberculosis have reduced antibiotic susceptibility |
| 3:10 pm – 3:25 pm | Short Talk: Kyle Gibbs (Duke University) Natural genetic variation in mucolipin-2 restricts Salmonella Typhi replication inside human leukocytes through magnesium deprivation |
| 3:25 pm – 3:55 pm | Business Meeting |
| 3:55 pm – 4:10 pm | Wrap-up by Conference Organizers |
