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Agenda
Please note that all times listed currently reflect US Eastern Time (ET). The schedule is subject to change. Presentations are pre-recorded followed by live Q&A.Tuesday, June 15, 2021
| Time | Event |
| 10:00 am – 10:10 am | Welcome: Vera Gorbunova, Andreas Guse, Raul Mostoslavsky, & W. Lee Kraus |
| 10:10 am – 10:35 am | NAD + Signaling Keynote #1: Organellar Ca2+ regulators (OCaRs) determining NAADP-mediated Ca2+ release from acidic intracellular stores in pancreatic acinar cells and cardiomyocytes Marc Freichel (Heidelberg University) |
| 10:35 am – 10:50 am | Short Talk #1: NAADP forming enzyme in T cells Feng Gu (University Medical Center Hamburg- Eppendorf) |
| 10:50 am – 11:05 am | Short Talk #2: HN1L/JPT2: a signaling protein connecting NAADP to Ca2+ microdomains Imrankhan Khansahib (University Medical Center Hamburg-Eppendorf |
| 11:05 am – 11:20 am | Short Talk #3: The rodenticide vacor induces activation of SARM1 by generation of a cytotoxic NAD analog in the nicotinamide salvage pathway Lars Sverkeli (University of Bergen) |
| 11:20 am – 11:35 am | Short Talk #4: Discovery and applications of a novel fluorescent probe of SARM1 Yongjuan Zhao (The Chinese University of Hong Kong (Shenzhen)) |
| 11:35 am – 12:00 pm | Keynote #2: Ligand recognition and gating mechanism of ADP ribose-sensitive TRPM2 channel Juan Du (early career) (Van Andel Institute) |
| 12:05 pm – 2:00 pm | Poster Session |
| 2:00 pm – 2:25 pm | Poly(ADP-ribosyl)ation and PARPs Keynote #1: Mono-ADP-ribosylation controls specific membrane transport routes Daniela Corda (National Research Council of Italy) |
| 2:25 pm – 2:40 pm | Short Talk #1: Chemical Proteomics Approach for Profiling the NAD Interactome Sunil Sundalam/Michael Cohen (Oregon Health & Science University) |
| 2:40 pm – 2:55 pm | Short Talk #2: Skeletal muscle Poly-ADP-Ribose Polymerase 1 (PARP1) ablation or inhibition decreases skeletal muscle mass and muscle fiber size Alexander Green (University of Ottawa) |
| 2:55 pm – 3:10 pm | Short Talk #3: Alphavirus ADP-ribosylhydrolase Activity Controls Stress Granule Dynamics Aravinthkumar Jayabalan (Johns Hopkins University) |
| 3:10 pm – 3:25 pm | Short Talk #4: Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal Johannes Rack (University of Oxford) |
| 3:25 pm – 3:50 pm | Keynote #2: Serine ADP-ribosylation by HPF1/PARP1 as a versatile technology for exploring multiple ADPr signals Ivan Matic (early career) (Max Planck Institute for Biology of Ageing) |
| 4:00 pm – 5:00 pm | Meet the Editors - Rosalind Mott, Cell Metabolism; Christoph Schmitt, Nature Metabolism |
Wednesday, June 16, 2021
| Time | Event |
| 10:00 am – 10:10 am | Welcome: Vera Gorbunova, Andreas Guse, Raul Mostoslavsky, & W. Lee Kraus |
| 10:10 am – 10:35 am | Sirtuins Keynote #1: David Sinclair (Harvard University) |
| 10:35 am – 10:50 am | Short Talk #1: NADH-SIRT1 Redox Axis Controls Transcription and Rhythmic Metabolism Daniel Levine (Northwestern University) |
| 10:50 am – 11:05 am | Short Talk #2: The balance between SIRT6-mediated DNA repair and LINE1-suppression controls resistance to DNA damage and lifespan in mice Matt Simon (University of Rochester) |
| 11:05 am – 11:20 am | Short Talk #3: A centenarian variant of SIRT6 enhances genome maintenance activity
Jonathan Gigas/Andrei Seluanov (University of Rochester)
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| 11:20 am – 11:35 am | Short Talk #4: Purine nucleoside phosphorylase controls nicotinamide riboside metabolism in mammalian cells Andrey Nikiforov (Institute of Cytology, Russian Academy of Sciences) |
| 11:35 am – 12:00 pm | Keynote #2: SIRT6 in DNA repair and age-related disease Debbie Toiber (early career) (Ben Gurion University of the Negev) |
| 12:05 pm – 1:00 pm | Meet the Speakers |
| 1:00 pm – 2:00 pm | ROUNDTABLE DISCUSSION: Benefits of Joining a Scientific Professional Society – Joining a scientific professional society offers many benefits beyond discounted meeting registration rates and journal subscriptions. This discussion will explore how joining a society helps scientists build their network, find mentors, explore professional development opportunities, advance their career, and give back to their profession. It will also provide tips for maximizing the value of your membership in a society. HOST: Mary-Ann Bjornsti, PhD, FASEB Vice President-Elect for Science Policy/ University of Alabama at Birmingham |
| 2:00 pm – 2:25 pm | Metabolism and Interventions Keynote #1: Shin Imai (Washington University) |
| 2:25 pm – 2:40 pm | Short Talk #1: Evolution of histone-mediated compartmental regulation of NAD metabolism Iva Guberovic/Marcus Buschbeck (Josep Carreras Leukaemia Research Institute) |
| 2:40 pm – 2:55 pm | Short Talk #2: NAD precursors cycle between host tissues and the gut microbiome Karthikeyani Chellappa (University of Pennsylvania) |
| 2:55 pm – 3:10 pm | Short Talk #3: MCART1/SLC25A51 is required for mitochondrial NAD transport Nora Kory (Harvard T.H. Chan School of Public Health |
| 3:10 pm – 3:25 pm | Short Talk #4: Improved liver regeneration following nicotinamide riboside supplementation requires hepatocyte lipolysis Sarmistha Mukherjee (University of Pennsylvania) |
| 3:25 pm – 3:50 pm | Keynote #2: Compartmentalized Regulation of Intracellular NAD+ Lulu Cambronne (early career) (University of Texas at Austin) |
| 4:00 pm – 5:00 pm | Social Hour |
