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Agenda
The Mobile DNA Conference: Evolution, Diversity, and ImpactAll talks will be either pre-recorded or presented live, with live question/answer periods following each session. All events are taking place in Eastern Daylight Time. The agenda is subject to change.
Day I - Tuesday, June 8, 2021
| Time | Event |
| 08:15 am – 08:30 am | Conference Opens - Welcome Day I Conference Chair: Victoria Belancio Co-Organizers: David A. Largaespada; Molly Gale Hammell; Josefa Gonzalez; Steven N. Austad |
| 08:30 am – 09:20 am | Keynote Lecture: Zsuzsanna Izsvak Titled: A junk to treasure? |
| 09:20 am – 09:30 am | Live Q&A with the Keynote |
| 09:30 am – 11:30 am | Session I: Tools and Resources for Studies Involving TEs Session Chair: Gael Cristofari |
| 09:30 am – 09:55 am | Paul Flicek “Resources, their use, and what’s new?” |
| 09:55 am – 10:20 am | Jef Boeke An unexpected function for an Alu sequence |
| 10:20 am – 10:30 am | Live Q&A Panel Discussion |
| 10:30 am - 10:55 am | Alice Lee Detection of de novo TE inserts – progress and technical barriers |
| 10:55 am – 11:20 am | Prescott Deininger Detection of TE mRNA expression – short versus long reads, single cell approaches, malignant versus normal cells |
| 11:20 am – 11:30 am | Live Q&A Panel Discussion |
| 11:30 am - 11:40 am | Short Talk 1 Jessica Storer Curation guidelines for de novo generated transposable element families |
| 11:40 am – 11:50 am | Short Talk 2 Raquel Garza Expression of LINE-1 elements in the developing and mature human brain at single-cell type resolution |
| 11:50 am - 12:00 pm | Short Talk 3 Wilson McKerrow LINE-1 Retrotransposon expression in cancerous, epithelial and neuronal cells revealed by 5'-single cell RNA-Seq |
| 12:00 pm – 12:15 pm | Live Q&A Panel Discussion |
| 12:15 pm – 12:30 pm | Break |
| 12:30 pm – 2:00 pm | Poster Session I |
| 2:00 pm – 3:30 pm | Session II: TE Evolution and Diversity Session Chair: Josefa Gonzalez |
| 2:00 pm – 2:25 pm | Susan Wessler Deciphering the strategies evolved by a very successful transposable element |
| 2:25 pm – 2:50 pm | Cristina Vieira Transposable elements in Drosophila suzukii invasive species |
| 2:50 pm – 3:15 pm | David Ray TE diversity in mammalian genomes |
| 3:15 pm – 3:30 pm | Live Q&A Panel Discussion |
| 3:30 pm – 3:40 pm | Short Talk 4 Thomas Carter Mosaic cis-regulatory evolution drives human endogenous retrovirus HERV-H transcriptional partitioning |
| 3:40 pm – 3:50 pm | Short Talk 5 Jennifer Frost Functional evaluation of transposable elements as enhancers in human trophoblast |
| 3:50 pm - 4:00 pm | Short Talk 6 Rachel Cosby Investigating the role of the host-transposase fusion gene THAP7 in vertebrate neurodevelopment and human intellectual disability |
| 4:00 pm – 4:15 pm | Live Q&A Panel Discussion |
| 4:15 pm – 4:30 pm | Break |
| 4:30 pm – 5:30 pm | Social Hour/history of the TE field – a Discussion that will Reflect on the Discovery of TEs and Tools Social Hour Moderator: Victoria Belancio Leaders: Haig Kazazian, Perry Hackett, Zsuzsanna Izsvak, Susan Wessler, John Moran, Prescott Deininger, Dixie Mager, Zoltan Ivics and Nancy Craig |
| 5:30 pm - 5:45 pm | Conclusion - End of Day I |
Day II - Wednesday, June 9, 2021
| Time | Event |
| 08:15 am – 08:30 am | Conference Opens - Welcome Day II Conference Chair: Victoria Belancio |
| 08:30 am – 10:30 am | Session III: Mechanisms of TE Mobilization - Its Impact on Disease and Treatment Session Chair: Molly Gale Hammell |
| 08:30 am – 08:55 am | John Moran Studies of a human retrotransposon |
| 08:55 am – 09:20 am | Kathleen Burns TE mobilization in cancers – contribution to transformation and progression |
| 09:20 am – 09:30 am | Live Q&A Panel Discussion |
| 09:30 am - 09:55 am | David Largaespada TEs as gene discovery tools - somatic cell, cell line, germline tools in vertebrates |
| 09:55 am – 10:20 am | Drew Deniger Development of Sleeping Beauty transposed TCR-T cells for adoptive cell therapy of cancer |
| 10:20 am – 10:30 am | Live Q&A Panel Discussion |
| 10:30 am - 10:45 am | Break |
| 10:45 am – 10:55 am | Short Talk 7 Luz Jubierre Zapater PGBD5 DNA transposase induces DNA damage in the brain and is required for its correct development |
| 10:55 am – 11:05 am | Short Talk 8 Gerald Schumann Cytoplasmic synthesis of endogenous Alu complementary DNA by LINE-1 mediated reverse transcription is a cause for age-related macular degeneration (AMD) |
| 11:05 am – 11:15 am | Short Talk 9 Kasia Siudeja Unraveling the features of somatic transposition in the Drosophila intestine |
| 11:15 am – 11:25 am | Short Talk 10 Katsumi Yamaguchi Striking heterogeneity of somatic L1 retrotransposition in single normal and cancerous gastrointestinal cells |
| 11:25 am – 11:45 am | Live Q&A Panel Discussion |
| 11:45 am – 12:00 pm | Break |
| 12:00 pm – 1:00 pm | Career Development Session Moderator: Victoria Belancio Speakers: Amy Lossie, Program Director - Genetics, Epigenetics and Developmental Neuroscience Branch, NIDA Ian Fingerman, Program Director - DNA and Chromosome Aberrations Branch, Division of Cancer Biology, NCI Career Development presentation and discussion for students, postdocs and juniors PIs, but all conference participants are encouraged to attend. |
| 1:00 pm – 1:15 pm | Break |
| 1:15 pm – 2:30 pm | Session IV: TEs, Genetics, and Epigenetics Session Chair: Rita Rebollo |
| 1:15 pm – 1:40 pm | Rob Martienssen LTR retrotransposons, epigenetics, and small RNAs |
| 1:40 pm – 1:50 pm | Short Talk 11 Kenji Ichiyanagi B2 SINE copies serve as a transposable boundary of DNA methylation and histone modifications in the mouse |
| 1:50 pm - 2:00 pm | Short Talk 12 Nelson Lau Transposable element landscape changes are buffered by RNA silencing in aging Drosophila |
| 2:00 pm – 2:10 pm | Short Talk 13 Sophie Lanciano Young human LINE-1 retrotransposons and their target loci are subject to multiple and cell type-specific layers of epigenetic regulation |
| 2:10 pm – 2:30 pm | Live Q&A Panel Discussion |
| 2:30 pm – 3:30 pm | Poster Session II |
| 3:30 pm – 5:00 pm | Session V: Genome Stability and Aging Session Chair: Victoria Belancio |
| 3:30 pm – 3:55 pm | Judith Campisi DNA Repair, Cancer, and Aging |
| 3:55 pm – 4:20 pm | Felipe Sierra Geroscience 101 |
| 4:20 pm – 4:45 pm | Steven Austad Sex differences in aging and disease in model and non-model organisms |
| 4:45 pm – 5:00 pm | Live Q&A Panel Discussion |
| 5:00 pm – 5:15 pm | Final Remarks - Conclusion of Day II Conference Chair: Victoria Belancio |
