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Tuesday, May 25, 2021

Time Central Time (CT)*	Event
8:45 am – 9:00 am	Welcome and Introductions: Dan Frigo (University of Texas MD Anderson Cancer Center) & Eric Prossnitz (University of New Mexico)
9:00 am – 9:30 am	Keynote Address: Donald McDonnell (Duke University School of Medicine) “If We Knew Then What We Know Now, What We Would Have Done Differently to Exploit Nuclear Receptors as Drug Targets”
9:30 am – 9:45 am	Discussion
9:45 am – 12:00 pm	Nuclear Steroid Receptor Regulation of Macrometabolism Discussion Leaders: Gian Paolo Rossi (University of Padova) & Sayeepriyadarshini Anakk (University of Illinois)
9:45 am – 10:00 am	Adriana Maggi (University of Milan) “Liver Estrogen Receptors and Metabolic Function”
10:00 am – 10:15 am	Carolyn Cummins (University of Toronto) “Glucocorticoid-induced obesity is mitigated by LXRβ in mice”
10:15 am – 10:30 am	Andrea Hevener (UCLA) “Estrogen Regulation of Insulin Actions”
10:30 am – 10:45 am	Joint Discussion
10:45 am – 11:00 am	Break
11:00 am – 11:15 am	Sheng Wu (Johns Hopkins University) “Nuclear and Extranuclear Hepatic Androgen Receptor Action in Insulin Resistance in Females”
11:15 am – 11:30 am	Brian Feldman (UCSF) “The glucocorticoid receptor links food consumption to adipocyte stem cell activity”
11:30 am – 11:45 am	Wen Xie (University of Pittsburgh) “Sex and Tissue-specific Roles of Estrogen Sulfotransferase and Steroid Sulfatase in Energy Metabolism”
11:45 am – 12:00 pm	Warren Thomas (Royal College of Surgeons in Ireland) “Aldosterone regulation of renal Na+ reabsorption via novel protein kinase D isoforms”
12:00 pm – 12:15 pm	Joint Discussion
12:15 pm – 1:00 pm	Break
*12:15 pm – 1:00 pm*	ROUNDTABLE DISCUSSION (to take place on the virtual platform): Science Policy Fellowships – learn about FASEB and FASEB member society-sponsored fellowship opportunities for students and postdocs interested in pursuing a career in science policy. Will include discussion about upcoming openings for U.S. citizens as well as non-citizens, skills that are transferable, and tips for applicants. HOST: Yvette Seger, PhD, FASEB Director of Science Policy
1:00 pm – 3:15 pm	Clinical Aspects of Therapies Targeting Steroid Hormone Receptors Discussion Leaders: Jay Gertz (Huntsman Cancer Institute/University of Utah School of Medicine) & Martin Wehling (University of Heidelberg)
1:00 pm – 1:15 pm	Iris Jaffe (Tufts University) “Vascular MR: Evolutionary Mediator of Wound Healing Turned Harmful by Our Modern Lifestyle”
1:15 pm – 1:30 pm	James Pru (University of Wyoming) “PGRMC1 and PGRMC2 Functions in Uterine Physiology and Disease”
1:30 pm – 1:45 pm	Paul Davis (Albany Medical College, NanoPharmaceuticals LLC) “Targeting non-genomic thyroid signaling for the treatment of glioblastoma”
1:45 pm – 2:00 pm	Joint Discussion
2:00 pm – 2:15 pm	Break
2:15 pm – 2:30 pm	Wilbert Zwart (Netherlands Cancer Institute) “Cistromics in Clinical Trials: From Markers to Mechanisms”
2:30 pm – 2:45 pm	Mathieu Lupien (University of Toronto) “Epigenetics of Hormone-dependent Cancer”
2:45 pm – 3:00 pm	Lightning round of selected 3-minute poster abstracts: Florian Le Billan (University of Toronto) "The nuclear receptor coregulator ARGLU1 potentiates glucocorticoid-induced insulin resistance and type 2 diabetes" Alicia Arredondo Eve (University of Illinois at Urbana-Champaign) "Identification of diagnostic plasma biomarkers of coronary microvascular disease in postmenopausal women using machine learning methods" Ximena Calle Chalco (Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences, University of Chile) "17-β estradiol regulates MUL1 and cardiomyocyte hypertrophy" Innocence Harvey (Pennington Biomedical Research Center (LSU)) "Artemisia scoparia Attenuates Glucocorticoid-Induced Lipolysis" Jia Xu Li (University of Toronto) "Disruption of Adipose Tissue Metabolism by Glucocorticoids is Attenuated with LXRβ Antagonism"
3:00 pm – 3:15 pm	Joint Discussion
3:15 pm – 3:30 pm	Break
3:45 pm – 5:00 pm	Poster Session

Wednesday, May 26, 2021

Time Central Time (CT)*	Event
9:30 am – 9:45 am	Day Two: Welcome
9:45 am – 12:00 pm	Systems Biology to Deconstruct Nuclear Steroid Receptor Mechanisms and Functions Discussion Leaders: Andrea Cignarella (University of Padova) & Lindsey Trevino (City of Hope)
9:45 am – 10:00 am	Trevor Archer (NIEHS) "GR activated transcription in single cells and individual genes"
10:00 am – 10:15 am	Fabio Stossi (Baylor College of Medicine) “Imaging Nuclear Receptor Actions at the Single Cell Level”
10:15 am – 10:30 am	Pierre Gourdy (University of Toulouse) “Estrogen receptor subcellular localization and cardiometabolism”
10:30 am – 10:45 am	Joint Discussion
10:45 am – 11:00 am	Break
11:00 am – 11:15 am	Lee Kraus (UTSW) “Molecular Mechanisms of Estrogen Receptor Enhancer Assembly and Function”
11:15 am – 11:30 am	Marc Tatar (Brown University) “Steroid GPCR-mediated Renal Fibrosis Modeled in Drosophila”
11:30 am – 11:45 am	Lightning round of selected 3-minute poster abstracts Eriko Katsuta (Roswell Park Comprehensive Cancer Center) "Transcriptional regulation of extracellular adenosine synthesis in estrogen receptor (ER)-positive breast cancer" Ayca Mogol (University of Illinois at Urbana-Champaign) "Elucidating lung-niche specific transcriptomic changes of metastatic ER+ breast tumors" Qianying Zuo (University of Illinois at Urbana-Champaign) "Targeting metabolic adaptations in the breast cancer-liver metastatic niche nexus using dietary approaches to improve endocrine therapy efficacy" Kendall Langsten (Wake Forest School of Medicine) "Spontaneous Bone Metastasis and Antiestrogen Response in a Novel Estrogen Receptor-Positive Murine Breast Cancer Model"
11:45 am – 12:00 pm	Joint Discussion
12:00 pm – 12:15 pm	Break
12:15 pm – 1:15 pm	Career Development Workshop: “Presenting Your Science to the Public” The Endocrine Society
1:15 pm – 2:00 pm	Break
2:00 pm – 4:15 pm	Steroid hormone actions in the brain Discussion Leaders: Paul Mermelstein (University of Minnesota) & Martin Kelly (Oregon Health & Science University)
2:00 pm – 2:15 pm	Gabriele Rune (University of Hamburg) “Sex-dependent Effects of Neurosteroids in the Hippocampus”
2:15 pm – 2:30 pm	Charlotte Cornil (University of Liège) “Cooperation of nuclear and membrane-actions of neuroestrogens in the control of male sexual behavior”
2:30 pm – 2:45 pm	Margaret Mohr (UCLA) “Pubertal development of estradiol-induced hypothalamic progesterone synthesis”
2:45 pm – 3:00 pm	Joint Discussion
3:00 pm – 3:15 pm	Break
3:15 pm – 3:30 pm	Kevin Sinchak (California State University, Long Beach) “Neuroprogesterone and PR regulation of LH surge”
3:30 pm – 3:45 pm	John Meitzen (North Carolina State University) “Estradiol Rapidly Modulates Excitatory Synapse Properties in the Nucleus Accumbens Core”
3:45 pm – 4:00 pm	Karyn Frick (University of Wisconsin-Milwaukee) “Targeting estrogen receptor beta as a treatment for alleviating memory loss and hot flashes”
4:00 pm – 4:15 pm	Lightning round of selected 3-minute poster abstracts Michael Saikali (University of Toronto) "Targeted temporal quantification of nuclear receptors by mass spectrometry" Dominik Awad (University of Texas MD Anderson Cancer Center) "AR-CAMKK2-AMPK signaling promotes prostate cancer progression by increasing intracellular lipolysis" Ashlie Santaliz (University of Illinois) "Evaluating metabolic and oncogenic pathways that impact aggressiveness of breast cancer in African American women" Cameron Leyers (Medical University of South Carolina) "Altered ERα localization differentially modulates immune cell subsets"
4:15 pm – 4:30 pm	Joint Discussion
4:30 pm – 5:00 pm	Flex Time

Thursday, May 27, 2021

Time Central Time (CT)*	Event
9:30 am – 9:45 am	Day Three: Welcome
9:45 am – 12:00 pm	Novel Functions of Steroid Receptors in Cancer Discussion Leaders: Christy Hagan (University of Kansas Medical Center) & Stephen Hammes (University of Rochester Medical Center)
9:45 am – 10:00 am	Rosamaria Lappano (University of Calabria) "New findings on the action of GPER in breast cancer”
10:00 am – 10:15 am	Carol Lange (University of Minnesota) “PR and GR - functionally redundant signaling properties in stemness”
10:15 am – 10:30 am	Lightning round of selected 3-minute poster abstracts Anasuya Das Gupta (University of Illinois, Urbana Champaign) "Mechanisms by which 27-Hydroxycholesterol modulates Extracellular Vesicle biogenesis" Sarah El Kharraz (KU Leuven, Molecular and Cellular Medicine) "Dimerization of the ligand-binding domain is crucial for normal functioning of the androgen receptor in mice" Asmaa El-Kenawi (Moffitt Cancer Center) "Tumor - macrophage metabolic interactions regulate androgen biosynthesis to induce therapeutic resistance in prostate cancer" Wanting Han (University of Massachusetts Boston) "CDK4/6 inhibitor enhances the tumor-suppressive activity of high-dose androgen in castration-resistant prostate cancer" Thu Truong (University of Minnesota) "PELP1/SRC-3-dependent regulation of metabolic PFKFB kinases drives therapy resistant ER+ breast cancer"
10:30 am – 10:45 am	Joint Discussion
10:45 am – 11:00 am	Break
11:00 am – 11:15 am	Marina Holz (New York Medical College) “Crosstalk between mTOR and estrogen signaling”
11:15 am – 11:30 am	Matt Sikora (University of Colorado, School of Medicine) “Unique Estrogen Receptor Biology Underlies Therapy Response and Resistance in Lobular Carcinoma”
11:30 am – 11:45 pm	Scott Tomlins (Strata Oncology) “High-throughput "Omics" to Identify Driver Mutations and Gene Fusions in Cancer”
11:45 pm – 12:00 pm	Joint Discussion
12:00 pm – 1:00 pm	Break
1:00 pm – 2:45 pm	Targeting Steroid Receptors: New Mechanisms Discussion Leaders: Donald DeFranco (University of Pittsburgh) & Ellis Levin (University of California- Irvine)
1:00 pm – 1:15 pm	Elahe Mostaghel (Fred Hutchinson Cancer Center) “Adrenal androgens and AR axis inhibition in prostate cancer – mechanism of resistance and predictors of response”
1:15 pm – 1:30 pm	Douglas Kojetin (Scripps Research-Florida) “Ligand-induced PPARγ repression made crystal clear with NMR spectroscopy”
1:30 pm – 1:45 pm	Joint Discussion
1:45 pm – 2:00 pm	Break
2:00 pm – 2:15 pm	Edward Filardo (University of Iowa) “Dual specificity PROTACs that target plasma membrane and intracellular estrogen receptors”
2:15 pm – 2:30 pm	John Katzenellenbogen (University of Illinois) “Unusual Effects of Estrogens Through Estrogen Receptor Beta and From Very Low Affinity Ligands”
2:30 pm – 2:45 pm	Joint Discussion
2:45 pm – 3:00 pm	Break
3:00 pm – 4:45 pm	Nuclear Steroid Receptor/Metabolic Crosstalk Discussion Leaders: Kristy Brown (Weill Cornell Medicine) & Subhamoy Dasgupta (Roswell Park Comprehensive Cancer Center)
3:00 pm – 3:15 pm	Ian Mills (Queens University Belfast) “AR-regulated Metabolism in Prostate Cancer”
3:15 pm – 3:30 pm	Rebecca Riggins (Georgetown University) “ERR Metabolism in Breast Cancer, Metabolism in GBM”
3:30 pm – 3:45 pm	Joint Discussion
3:45 pm – 4:00 pm	Break
4:00 pm – 4:15 pm	Giorgia Zadra (Institute of Molecular Genetics, National Research Council-Italy) “Modulation of intra-tumor lipid metabolism is a non-canonical approach to target AR receptor"
4:15 pm – 4:30 pm	Erik Nelson (University of Illinois) “Cholesterol, ER and LXRs Functions in the Breast Cancer Metastatic Tumor Microenvironment”
4:30 pm – 4:45 pm	Phil Shaul (UTSW) “Estrogen Receptor Signaling in Endothelium in Cardiometabolic Health and Disease”
4:45 pm – 5:00 pm	Joint Discussion
5:00 pm – 5:15 pm	Wrap-up by Conference Organizers