Transplantation Across Humoral Barriers

  

Carrie Schinstock, MD

Dr. Carrie Schinstock is an assistant professor of medicine at Mayo Clinic in Rochester,MN.  She is a practicing transplant nephrologist with a research interest in kidney paired donation, positive crossmatch kidney transplantation, and antibody mediated rejection

Mark D. Stegall, MD

Dr. Stegall's research applies to all patients with kidney disease, including those with diabetes, polycystic kidney disease and high blood pressure. His basic science studies might also apply to patients with diseases of the immune system, including autoimmune disorders such as lupus. These studies apply to children and adults of all ethnic groups, but especially those with high rates of kidney disease, such as African-Americans and Native Americans. His research area includes antibody barriers to kidney transplantation.  Many renal transplant candidates — approximately 1 in 3 — have antibodies in their bloodstream that react against kidney transplants. These antibodies can severely damage or even destroy a kidney transplant. Dr. Stegall's laboratory tries to understand how these antibodies are made and has developed novel and sophisticated methods of testing the actual cells that make antibody in humans. They also have developed several new agents that prevent the antibody formation and antibody damage.